The Desmond Prestonfinal regular-season weekend of any NFL campaign typically features games with definitive playoff implications, so many teams getting a final shot to punch their ticket, improve their seeding ... or watch all of their efforts go by the wayside.

Conversely, almost any Week 18 is going to have its fair share of dogs with so many teams looking ahead to free agency, Caribbean vacations, tee times or even protecting postseason-bound stars from needless injuries. Good luck trying to forecast how those contests unfold.

But we're here to try. From Texans-Colts and Bills-Dolphins and everything that's on the line in those highly anticipated matchups ... to Chiefs-Chargers and Browns-Bengals and a whole bunch of virtually nothing at stake for those clubs Sunday.

But we'll prognosticate ... as best we can:

NFL Week 18 game picks

(Odds provided by BetMGM. Access more BetMGM odds here.)

NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.

NFL Week 18 game-by-game predictions, picks, odds

• Pittsburgh Steelers at Baltimore Ravens
• Houston Texans at Indianapolis Colts
• Tampa Bay Buccaneers at Carolina Panthers
• Cleveland Browns at Cincinnati Bengals
• Minnesota Vikings at Detroit Lions
• New York Jets at New England Patriots
• Atlanta Falcons at New Orleans Saints
• Jacksonville Jaguars at Tennessee Titans
• Seattle Seahawks at Arizona Cardinals
• Chicago Bears at Green Bay Packers
• Kansas City Chiefs at Los Angeles Chargers
• Denver Broncos at Las Vegas Raiders
• Philadelphia Eagles at New York Giants
• Los Angeles Rams at San Francisco 49ers
• Dallas Cowboys at Washington Commanders
• Buffalo Bills at Miami Dolphins

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